It may be possible to generate standard ready-made products at reduced cost and manufacturing time. With sufficiently accrued database for bone imaging, manufacturing time is expected to be curtailed.

In such cases, CT scans are used to model the bone structures. Findings on the efficacy of whitlockite as a synthetic bone graft material is currently awaiting publication as an original article in an internationally recognized medical journal.ДЄdditionally, 3D printing technology have been incorporated to create 'patient-specific bone implants' based on whitlockite synthetic material. Osfirm is preparing to submit applications to the Korean Ministry of Food and Drug Safety by 2022 for approval of IND on whitlockite-based bone implants, and if approved, is expecting to begin the clinical trials by year 2023. For this reason, the medical community began to seek different substances leading to the discovery of whitlockite. Whitlockite based synthetic bone is an innovative alternative to allograft bone from a human cadaver which is both costly and considered barbaric by many patients and xenograft bone from animal recipients which presents risks of allograft rejection and infection.ДЄnd the existent synthetic bone graft materials using hydroxyapatite and tricalcium beta phosphate are relatively inexpensive but present limitations in bone regenerative and reconstructive abilities. For example, in dentistry, it is a material used to firmly fix the implant by implanting it in the implant site. One patented technology involves the development of synthetic bone graft based on whitlockite. Osfirm holds 7 patents to this day on the various methods for manufacturing whitlockite and has completed registry of the substance with the American Chemical Society. With regard to the legal issues on patents, the substance itself may not be patentable but its manufacturing process is eligible for patents. Product Line Diversity Ranging from 3D Printing Customizable Implant to Absorbable Composite Bone Bonding Plates and Screws The CEO, Professor Chan Yeong Heo is also the Head of the Regenerative Medical Center at Seoul National University Bundang Hospital.

Osfirm was established within the Healthcare Innovation Center of Seoul National University Bundang Hospital, one of the most prestigious medical institutions in Korea. In 2018, a Korean bio-venture company was founded based on the manufacturing and mass production technology of 'high-purity Whitrokite' that mimetics the structure of inorganic substances present in human bones. Whitlockite is a unique form of magnesium tricalcium phosphate that has shown superior bioactive regenerative and reconstructive properties and excellent biocompatibility, making it an ideal biomaterial for implant use on sites of fracture or bone defects. 28, 2021 /PRNewswire/ - In 1941, 'whitlockite,' the second most abundant inorganic mineral of the bone was named in honor of Herbert Whitlockite, Curator of Minerals and Gems in the American Museum of Natural History in New York.

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